Creutzfeldt-Jacob disease presenting as severe depression: a case report
نویسندگان
چکیده
BACKGROUND An 81 year old female presented with altered mental status after new onset of severe depression and suicidal ideation with recent psychiatric hospitalization. CASE PRESENTATION Key clinical features included muscle rigidity, prominent startle reflex, and rapidly progressing cognitive decline. Initial working hypothesis was serotonin syndrome or neuroleptic malignant syndrome but continued deterioration after medication removal prompted evaluation for alternative etiology. Work-up revealed elevated 14-3-3 CSF protein which suggested the prion disorder which was confirmed on post-mortem examination of brain tissue. CONCLUSION While the degree of depression was unusually severe, the case highlights the behavioral and psychiatric manifestations which frequently accompany Creutzfeldt-Jacob disease.
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1. Mehndiratta MM, Bajaj BK, Gupta M et al : Creutzfeldt-Jacob disease : Report of 10 cases from North India. Neurol India 2001; 49 : 338-341. 2. Shankar SK, Satish Chandra P : Creutzfeldt-Jacob disease – Cases in India in 30 years (1968-1997). CJD Registry NIMHANS, Bangalore, India. 3. Singhal BS, Dastur DK : Creutzfeldt – Jacob Disease in Western India. Observation in 7 patients. Neuroepidemi...
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